| 研究課題 |
１．ウマヘルペスウイルス１型の病原因子ならびに感染防御機序の解析
２．ウイルス性感染症の疫学的研究
３．腫瘍のミサイル療法に関する研究 |
| 著書・論文など |
＜著書＞
1) 馬鼻肺炎．近代出版 動物の感染症（第二版） p164 2006
2) 馬媾疹．近代出版 動物の感染症（第二版） p167 2006
3) ポリオーマウイルス科．文永堂 獣医感染症カラーアトラス（第二版） p342 2006
4) パピローマウイルス科．文永堂 獣医感染症カラーアトラス（第二版） p343 2006
5) 感染症とは何か？ 酪農総合研究所 酪農場の防疫：バイオセキュリティー pp9-23 2005
6) ポリオーマウイルスと感染症．文永堂 獣医微生物学（第二版） pp213-214 2003
7) パピローマウイルスと感染症．文永堂 獣医微生物学（第二版） pp215-217 2003
8) 海外からの感染症と対策．酪農学園大学エクステンションセンター 酪農ジャーナル 12：19－21 2003
＜論文＞
1) Onaga T, Sugita A, Wakaiki R, Hara I, Kagawa K, Kirisawa R, Hayashi H.Localization of CCK-1R in the omasum and role of CCK in the regulation of omasal contractions in sheep. Domest Anim Endocrinol. 2008; 35(2): 231-44.
2) 久枝啓一、有馬春樹、園部隆久、那須正信、萩原克郎、桐沢力雄、岩井 浤、永幡 肇．Escherichia coliによる乳牛の甚急性乳房炎における血清中および乳清中サイトカインの動態と臨床症状．日獣会誌．2008; 61(6):443-8.
3) Kirisawa R, Takeyama A, Koiwa M, Iwai H. Detection of bovine torovirus in fecal specimens of calves with diarrhea in Japan. J Vet Med Sci. 2007; 69(5): 471-6.
4) Hosaka Y, Ozoe S, Kirisawa R, Ueda H, Takehana K, Yamaguchi M. Effect of heat on synthesis of gelatinases and pro-inflammatory cytokines in equine tendinocytes. Biomed Res. 2006; 27(5): 233-41.
5) Kirisawa R, Hashimoto N, Tazaki M, Yamanaka H, Ishii R, Hagiwara K, Iwai H. Molecular characterization and functional expression of equine interleukin-1 type I and type II receptor cDNAs. Vet Immunol Immunopathol. 2006; 109(3-4): 219-31.
6) Hosaka Y, Kirisawa R, Ueda H, Yamaguchi M, Takehana K. Differences in tumor necrosis factor (TNF)alpha and TNF receptor-1-mediated intracellular signaling factors in normal, inflamed and scar-formed horse tendons. J Vet Med Sci. 2005; 67(10): 985-91.
7) Hagiwara K, Kitajima K, Yamanaka H, Kirisawa R, Iwai H. Development of a sandwich ELISA assay for measuring bovine soluble type II IL-1 receptor (IL1R2) concentration in serum and milk. Cytokine. 2005; 32(3-4): 132-6.
8) Kawasako K, Okamoto M, Kurosawa T, Nakade T, Kirisawa R, Miyashou T, Komine M, Go T, Imazu S, Takeuchi N, Tomonaga K, Ikuta K, Akihara Y, Shimoyama Y, Hirayama K, Taniyama H. Enzootic intranasal tumour virus infection in apparently healthy sheep in Japan. Vet Rec. 2005; 157(4): 118-20.
9) Hosaka Y, Kirisawa R, Mafune N, Takehana K. Downregulation of decorin and transforming growth factor-beta1 by decorin gene suppression in tendinocytes. Connect Tissue Res. 2005; 46(1): 18-26.
10) Kirisawa R, Hosoi Y, Yamaya R, Taniyama H, Okamoto M, Tsunoda N, Hagiwara K, Iwai H. Isolation of equine herpesvirus-1 lacking glycoprotein C from a dead neonatal foal in Japan. Arch Virol. 2005; 150(12): 2549-65.
11) Endoh D, Mizutani T, Kirisawa R, Maki Y, Saito H, Kon Y, Morikawa S, Hayashi M. Species-independent detection of RNA virus by representational difference analysis using non-ribosomal hexanucleotides for reverse transcription. Nucleic Acids Res. 2005; 33(6): e65.
12) Hagiwara K, Tokuda M, Baba T, Yamanaka H, Kirisawa R, Tsuji M, Ishihara C, Iwai H. The role of IFN-gamma in cattle infected with Theirelia sergenti. Vet Parasitol. 2005; 127(2): 105-10.
13) 平子 毅、久枝啓一、泉 賢一、黒澤 隆、萩原克郎、桐沢力雄、岩井 浤．牛新生子血清サイトカイン濃度と生後４ヶ月間の疾病発生状況との関連．酪農学園大学紀要 2005; 29(2): 171-5.
14) Hosaka Y, Sakamoto Y, Kirisawa R, Watanabe T, Ueda H, Takehana K, Yamaguchi M. Distribution of TNF receptors and TNF receptor-associated intracellular signaling factors on equine tendinocytes in vitro. Jpn J Vet Res. 2004; 52(3): 135-44.
15) Ishikawa Y, Nakada K, Hagiwara K, Kirisawa R, Iwai H, Moriyoshi M, Sawamukai Y. Changes in interleukin-6 concentration in peripheral blood of pre- and post-partum dairy cattle and its relationship to postpartum reproductive diseases. J Vet Med Sci. 2004; 66(11): 1403-8.
16) Yamanaka H, Hagiwara K, Kirisawa R, Iwai H. Transient detection of proinflammatory cytokines in sera of colostrum-fed newborn calves. J Vet Med Sci. 2003; 65(7): 813-6.
17) Kirisawa R, Kobayashi T, Uematsu R, Ikeda A, Kuroiwa R, Urakami A, Iwai H. Growth of recombinant equine herpesvirus 1 (EHV-1) replaced with passage-induced mutant gene 1 and gene 71 derived from an attenuated EHV-1 in cell cultures and in the lungs of mice. Vet Microbiol. 2003; 95(3): 159-74.
18) Yamanaka H, Hagiwara K, Kirisawa R, Iwai H. Proinflammatory cytokines in bovine colostrums potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression. Microbiol Immunol. 2003; 47(6): 461-8.
19) Okamoto M, Hagiwara K, Kamitani W, Sako T, Hirayama K, Kirisawa R, Tsuji M, Ishihara C, Iwai H, Kobayashi T, Tomonaga K, Ikuta K, Taniyama H. Experimental vertical transmission of Borna disease virus in the mouse. Arch Virol. 2003; 148(8): 1557-68. |
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